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Well you are asking for any CMS or the software on which you want to implement your coding? For CMS I think Joomla is good and website designing software adobe Dreamweaver and photoshop are good.

In my opinion Responsive Web Design should be in trend for the year 2013. Because its wonderful for great user experience across all devices.

I think Dreamweaver is a good option whether you are a designer or developer.

Yes absolutely content does matter, should try to get lots of quality back links to your website. Participate in communities and forum, try to gain some reputations.

Yeah my vote goes to Dreamweaver as well. I am using it since long and my experience with this is amazing.

That's very handy tips given. I appreciate it, will keep use of it.